Optimizing technologies for discovering cancer cell mutations

Cancer cells often have mutations in their DNA that can give scientists clues about how the cancer started or which treatment may be most effective. Finding these mutations can be difficult, but a new method may offer more complete, comprehensive results. A team of researchers has developed a new framework that can combine three existing … Read more

Same mutations underpin spread of cancer in individuals

Scientists have arrived at a key understanding about how cancers in individual patients spread, or metastasize, a study from the Stanford University School of Medicine and other collaborating institutions reports. The study found that mutations that drive cancer growth are common among metastases in a single patient. Most cancer-related deaths are caused by metastases, or … Read more

Mutations in this molecule may have helped mammoths tolerate the cold

Columbia University biomedical researchers have captured close-up views of TRPV3, a skin-cell ion channel that plays important roles in sensing temperature, itch, and pain. In humans, defects in the protein can lead to skin diseases such as atopic dermatitis (a type of eczema), vitiligo (uneven skin coloration), skin cancer, and rosacea. All vertebrate DNA, including … Read more