The novel by Olga, translated by Jennifer Croft, won the prize after coming top of a shortlist of six titles.
The money will be split between the author and translator. Tokarczuk is the author of eight novels and two short-story collections whilst Croft is an accomplished translator of Polish, Spanish and Ukrainian.
The Man Booker International Prize celebrates the English translations of works of international literature. The prize is a counterpart to the Man Booker Prize for English-language novels and is open to books in any language that have been translated into English.
The 50,000-pound ($67,000) award is split evenly between the writer and her translator, Jennifer Croft.